Klaus Klaushofer Selected Research

2-oxoglutarate 3-dioxygenase proline

1/2020	Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia.
4/2016	Bone matrix hypermineralization in prolyl-3 hydroxylase 1 deficient mice.
1/2016	Non-Lethal Type VIII Osteogenesis Imperfecta Has Elevated Bone Matrix Mineralization.

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Klaus Klaushofer Research Topics

Disease

20	Osteoporosis 01/2021 - 03/2003
15	Osteogenesis Imperfecta (Lobstein Disease) 01/2020 - 01/2005
10	Postmenopausal Osteoporosis 01/2022 - 08/2007
4	Vitamin D Deficiency 01/2018 - 08/2007
4	Pain (Aches) 01/2018 - 04/2005
4	Osteosarcoma (Osteogenic Sarcoma) 09/2017 - 03/2008
4	Femoral Fractures (Femoral Fracture) 06/2017 - 11/2010
3	Bone Resorption 01/2021 - 03/2002
3	Bone Diseases (Bone Disease) 10/2018 - 12/2004
3	Metabolic Bone Diseases (Osteopenia) 01/2018 - 12/2004
3	Osteomalacia 01/2018 - 12/2004
3	Hypophosphatemia 01/2018 - 12/2004
3	Stress Fractures (Stress Fracture) 01/2018 - 01/2015
3	Rickets (Rachitis) 01/2018 - 12/2004
3	Neoplasms (Cancer) 09/2017 - 04/2013
2	Hypoparathyroidism 01/2019 - 05/2009
2	Hypophosphatasia 10/2018 - 09/2015
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2018 - 09/2015
2	Hypocalcemia 01/2018 - 05/2009
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018 - 01/2018
2	Contracture 06/2017 - 08/2008
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 04/2016
2	Congenital Abnormalities (Deformity) 01/2015 - 01/2015
2	Chronic Kidney Failure (Chronic Renal Failure) 05/2013 - 02/2011
2	Leukemia 02/2011 - 03/2008
1	Melorheostosis 01/2020
1	Wounds and Injuries (Trauma) 01/2020
1	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2020
1	Developmental Bone Diseases (Bone Dysplasia) 01/2020
1	Hip Fractures (Intertrochanteric Fractures) 06/2019
1	Chronic Renal Insufficiency 01/2019
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 01/2019
1	Heart Arrest (Cardiac Arrest) 01/2018
1	Hyperferritinemia 01/2018
1	Crohn Disease (Crohn's Disease) 01/2018
1	Spontaneous Fractures (Pathological Fracture) 01/2018
1	Hemochromatosis (Bronze Diabetes) 01/2018
1	Hemorrhage 01/2018
1	Hip Osteoarthritis (Coxarthrosis) 01/2018
1	Hajdu-Cheney Syndrome (Multicentric Osteolysis) 11/2017
1	Hyperthyroidism 11/2017
1	Starvation 09/2017

Drug/Important Bio-Agent (IBA)

13	MineralsIBA 01/2021 - 10/2006
10	CalciumIBA 01/2022 - 01/2007
10	Diphosphonates (Bisphosphonates)IBA 11/2017 - 01/2005
7	Teriparatide (Parathar)FDA Link 01/2022 - 01/2009
7	CollagenIBA 01/2020 - 04/2004
7	Alendronate (Alendronate Sodium)FDA LinkGeneric 12/2018 - 01/2005
7	Risedronic Acid (Actonel)FDA LinkGeneric 05/2012 - 07/2006
6	Zoledronic Acid (Zometa)FDA Link 01/2021 - 12/2010
6	strontium ranelate (protelos)IBA 11/2011 - 01/2009
5	Collagen Type I (Type I Collagen)IBA 01/2020 - 03/2014
5	Phosphates (Orthophosphate)IBA 01/2020 - 12/2004
4	Vitamin D FDA LinkGeneric 01/2022 - 12/2004
4	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2015
4	Parathyroid Hormone (Parathormone)IBA 01/2018 - 03/2003
4	Ibandronic Acid (Boniva)FDA Link 06/2017 - 01/2009
3	2-oxoglutarate 3-dioxygenase prolineIBA 01/2020 - 01/2016
3	Bone Density Conservation AgentsIBA 11/2017 - 03/2009
3	Pamidronate (Aredia)FDA LinkGeneric 09/2017 - 09/2006
3	pyridinolineIBA 01/2017 - 11/2014
2	InterferonsIBA 01/2020 - 09/2017
2	Proton Pump InhibitorsIBA 06/2019 - 11/2010
2	Calcium-Sensing ReceptorsIBA 01/2019 - 05/2009
2	IronIBA 01/2018 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 02/2011
2	Procollagen Type IIBA 01/2018 - 06/2011
2	Denosumab FDA Link 06/2017 - 12/2010
2	diphosphoric acid (pyrophosphoric acid)IBA 06/2017 - 09/2015
2	GlucocorticoidsIBA 04/2016 - 11/2010
2	EnzymesIBA 09/2015 - 04/2004
2	Proteoglycans (Proteoglycan)IBA 11/2014 - 10/2014
2	alpha2 Subunit Collagen Type IIBA 10/2014 - 06/2011
2	Growth Hormone (Somatotropin)IBA 05/2013 - 01/2008
2	Raloxifene Hydrochloride (Evista)FDA Link 12/2010 - 01/2009
2	ElementsIBA 09/2009 - 08/2008
2	OsteoprotegerinIBA 05/2008 - 03/2002
2	Cathepsin KIBA 05/2008 - 04/2004
1	SaltsIBA 01/2021
1	YKL-05-099IBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	1,25-dihydroxyvitamin DIBA 01/2020
1	SphingomyelinsIBA 01/2019
1	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 10/2018
1	benzoyl L-arginine methyl ester (BAME)IBA 01/2018
1	Alkaline PhosphataseIBA 01/2018
1	Transferrin (beta 2 Transferrin)IBA 01/2018
1	Nonsense Codon (Nonsense Mutation)IBA 01/2018
1	Thyroxine (Levothyroxine)FDA LinkGeneric 11/2017
1	Drinking WaterIBA 11/2017
1	AntibodiesIBA 11/2017
1	CholesterolIBA 09/2017
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2017

Therapy/Procedure

15	Therapeutics 01/2022 - 09/2006
3	Drug Therapy (Chemotherapy) 01/2020 - 04/2013
2	Intravenous Infusions 01/2021 - 01/2018
2	Spinal Fusion (Spondylosyndesis) 01/2015 - 07/2007
2	Osteotomy 01/2015 - 01/2015
2	Aftercare (After-Treatment) 09/2011 - 03/2003
1	Replacement Arthroplasty 01/2018